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生物系統控制與醫療器材設計實驗室
Biosystem and Medical Device Design Laboratory

首頁: Welcome

RESEARCH DIRECTION

  • 空氣超音波懸浮; 操控; 環境感知/ Airborne ultrasound levitation; Manipulation; Environment sensing

  • 生物系統控制/ Bio system control

  • 治療用超音波/ Therapeutic ultrasound

 

  • 醫學電子/ Medical electronics

 

  • 醫療器材設計開發/ Medical device development​​

 

  • 擴增實境/ Augmented reality

首頁: About

Contactless Object Levitation and Position Control via Multiple-Channel Airborne Ultrasonic Array

Digital-Twin Establishment in Nvidia Omniverse of Airborne Ultrasound Array Realized by Physics-Informed Neural Operators (PINO)

Professor

劉浩澧 Hao-Li Liu

教授 Ph.D., Professor

劉浩澧博士在2003年取得國立臺灣大學電機工程博士學位。於2004-2005年期間,任職於美國波士頓哈佛大學醫學院/ Brigham & Womens Hospital放射科系擔任博士後研究員,從事治療超聲醫療儀器開發。於2005-2020年間任職於長庚大學電機系、並於2020年起加入國立台灣大學生醫資訊研究所。劉浩澧博士目前繼續研究治療用超音波之醫療器材技術開發,超音波輻照對血腦屏障(BBB)開啟進行大腦藥物輸送,超音波相位陣列設計等研究議題。劉博士在治療超音波領域發表了超過 120篇之SCI論文 (包含2篇被高引用論文)、 獲得超過40件全球專利。於2011及2018年,分別獲頒臺灣科技部吳大猷先生紀念獎、科技部傑出研究獎、及科技部傑出技轉貢獻獎。在國內。陸續榮獲電機工程學會優秀青年電機工程師獎及、永信李天德基金會青年醫藥科技奬、及有庠科技發明獎。在國際,曾榮獲國際超音波學會頒發Ferderic Lizzi Award,為第一位獲頒此獎之亞洲唯一學者。

Hao-Li Liu received the Ph.D. degrees in Electrical Engineering in 2003 from the National Taiwan University, Taipei, Taiwan. The current position is the Professor, Department of Electrical Engineering, National Taiwan University. In 2004-2005, He was the research fellow of the Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. He served as the Professor and the Director of Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan, and also the Adjunct Assistant Researcher of Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan. Dr. Liu is currently continuing research in ultrasound thermal therapy and its treatment planning/ simulation, ultrasound-induced blood brain barrier (BBB) disruption for brain drug delivery, ultrasound phased array design. Dr. Liu has published over 130 SCI papers, over 40 worldwide patents been filed in areas of biomedical use of therapeutic ultrasound. He received the Distinguished Tech-Coop Award and the Distinguished Research Award from Chang-Gung University, respectively. Also in 2011, He received the Wu Ta-You Memorial Award from the National Science Council in Taiwan. In 2013, he received the Frederic Lizzi Award from the International Society for Therapeutic Ultrasound (ISTU) and also the Excellent Young Electrical Engineer Award from the Chinese Institute of Electrical Engineering to acknowledge his significant research contributions to therapeutic ultrasound. In 2015, as the first engineering-background honoree, Dr. Liu received the TienTe Lee Award to recognize his contribution on integrating medicine and engineering. In 2017 and 2023, he received the Academic Research Award from the Ministry of Science and Technology, Taiwan. In 2020, He joined the Department of Electrical Engineering, National Taiwan University as a professor to continue his academic carrier. Dr. Liu is a senior member of IEEE and previously served as the board member in the International Society of Therapeutic Ultrasound (ISTU) and Taiwan Association of Interventional & Therapeutic Ultrasound (TAITU). Dr. Liu funded NaviFUS Inc. in 2015, dedicated to bring neuronavigation-guided focused ultrasound method to perform transcranial CNS drug delivery and neuromodulation with an outpatient treatment fashion. 

Award

2024, TECO Award, (東元科技獎) 
2023, Future Technology Breakthrough Award, National Science Council of Science and Technology(未來科技突破獎).
2022-present, World’s Top 2% Scientists in lifetime (全球前2%頂尖科學家,終身科學影響力排行), Elsevier/史丹佛大學.
2021-present, World’s Top 2% Scientists in single year (全球前2%頂尖科學家,年度科學影響力排行), Elsevier/史丹佛大學.
2023, Academic Research Award, National Science Council of Science and Technology (國科會/傑出研究獎)
2022, National Innovation Award (國家新創獎)
2021, The 18th National Innovation Award (國家新創獎/「臨床新創獎」類組)
2020, Outstanding Electrical Engineering Professor Award (傑出電機工程教授獎)
2020, The 7th Y. Z. Hsu Technology Invention Award (有庠科技發明獎)
2018, Acadamic Research Award, Ministry of Science and Technology (傑出研究獎)
2017, Future Technology Breakthrough Award, Ministry of Science and Technology (未來科技突破獎)
2017, Excellent Technology Transfer Award(傑出技轉貢獻獎), Ministry of Science and Technology, Taiwan..
2015, The 12th National Innovation Award (第12屆國家新創獎/「學研新創獎」類組).
2015, TienTe Lee Award (永信李天德醫藥科技獎/青年醫藥科技奬)
2013, Excellent Young Electrical Engineer Award (優秀青年電機工程師獎)
2013, Frederick Lizzi Early Career Award, by the International Society for Therapeutic Ultrasound (ISTU; 國際治療超音波學會).
2011, Wu Ta-You Memorial Award (吳大猷先生紀念獎), National Science Council, Taiwan.

Selected Publications

  1. ​KT Chen, WY Chai, YJ Lin, CJ Lin, PY Chen, HC Tsai, CY Huang, J Kuo, HL Liu*, KC Wei*, Neuronavigation-Guided Focused Ultrasound for Transcranial Blood-Brain-Barrier Opening and Immunostimulation in Brain Tumors, Science Advances, Vol. 7, pp. 1-13, eabd0772, 2021.

  2. CY Lin, CH Tsai, YC Lin, CY Huang, SR Wu, CM Chen, Hao-Li Liu*, “Ultrasound-Responsive Neurotrophic Factor-Loaded Microbubble-Liposome Complex: Preclinical Investigation for Parkinson's Disease Treatment,” Journal of Controlled Release, Vol. 321, pp.519-528, 2020.

  3. SG Chen, CH Tsai, CJ Lin, CC Lee, HY Yu, TH Hsieh, HL Liu*, “Transcranial focused ultrasound pulsation suppresses pentylenetetrazol induced epilepsy in vivo,” Brain Stimulation, Vol. 13, pp. 35-46, 2020. 

  4. CY Lin et al. and HL Liu*, “Ultrasound-Responsive Neurotrophic Factor-Loaded Microbubble-Liposome Complex: Preclinical Investigation for Parkinson's Disease Treatment,” Journal of Controlled Release, Vol. 321, pp.519-528, 2020.

  5. HL Liu et al., “Focused Ultrasound Enhances CNS Delivery of Bevacizumab for Malignant Glioma Treatment,” Radiology, Vol. 281, pp. 99-108, 2016.

  6. HL Liu et al., “Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain,” Proceedings of National Academy of Science USA, Vol. 107, No. 34, pp.15205-15210, 2010

More Publication: Google Scholar

首頁: Team

Postdoctoral Researcher

朱伯駿

In vivo Epilepsy

Thi-Thuyet Truong

Ultrasound neural stimulation

首頁: Team

Ph.D. student & Research assistant

Ph.D./ 李慧芳

.

Ph.D./ 黃聖涵

.

Ph.D./ 蔣易翰

.

首頁: Team

M.S. student

碩四/ 陳佳文

Treatment planning/ Animal Spine

碩三/ ​錢思達

Treatment planning/ Transcranial focused ultrasound

碩三/ 吳炯融

FPGA/ Ultrasound

碩三/ 蘇逸杰

FPGA/ Ultrasound system with negative feedback

碩二/ 劉東昇

.

碩二/ 黃邵陽

.

碩二/ 曾柏宇

.

碩二/ 陳孝倫

.

碩二/ 葉奕均

.

碩二/ 梁展維

.

碩二/ 蔡宜豐

.

碩二/ 羅宣融

.

首頁: Team

碩一/ 賴宥菖

.

碩一/ 鍾昇恩

.

碩一/ 王嘉德

.

碩一/ 黃品維

.

碩一/ 吳博皓

.

碩一/ 何旻學

.

碩一/ 周孟柏

.

碩一/ 張書寧

.

.

Former member

黃士瑜

Hololens AR/ Image assisted surgery

​賴正諺

Hololens AR/ Image assisted surgery

譚仕鑫

FPGA/ OCT

趙天易

Treatment planning/ Transcranial

羅敏宏

Camera AR/ Image assisted surgery

林易佑

FPGA/OCT

郭晨沅

FPGA/ Ultrasound

傅駿

Prodigy HIFU/ passive map

阮宜勁

FUS Neuromodulation for epilepsy/ fMRI in vivo /EEG in vivo

陳均懋

Driving Design for HIFU Application

甄瀟

fMRI in vivo/ MR-compatibe FUS

劉陶銘

Driving Design for HIFU Application

首頁: Team

李丞峰

FPGA/ Ultrasound

江承祐

FPGA/ OCT

謝子涔

Prodigy HIFU/ passive map

沈欣晨

Ultrasound Depicting Space

黃琛琁

In vivo GCamp

陳品如

FPGA/ Ultrasound

陳致揚

Hololens 2 AR / medical surgery

黃梓豪

Hololens 2 AR/ Ultrasound

​李永瀚

Transcranial/ Ultrasound in vivo study

譚富銘

Hololens 2 AR/ Ultrasound in medical surgery

洪國維

Deep learning/ Ultrasound

​楊曼永

Ultrasound

黃芯柔

FPGA/ Ultrasound

阮唯紘

fMRI/ EEG feedback FUS treatment in epilepsy

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